Assessment of the level of siga in the saliva as a biomarker of mucoosal immunity in Children

Abstract

In children, 24 patients aged 1 to 7 years were examined to assess the state of the immune system during acute respiratory infections (ARI) by determining the level of SIGA. According to the age composition, patient children were divided into the following groups: from 1 to 2 years - to group I (n = 6; 25.6%), from 3 to 5 years - to group II (n = 11; 43.9%), from 5 to 7 years up to group III (n = 7; 30.5%). In 11 children aged 1-4 years with ARI, a decrease in oral sIgA was found during the acute phase of the disease. Of these, 8 (72.7%) children had an average level of 33.78 ± 8.9 mcg / l, and 3 (27.3%) patients did not have sIgA in their saliva (<5 mcg / l). Decreased oral sIgA was reported in 70.5% of patients aged 5-7 years (13 people). During the early convalescence, sIgA increased from the previous low level and reached 138.45 ± 24.86 mcg / l in healthy children (p = 0.003). An early increase in sIgA 238.8 ± 57.39 mcg / l in 4 (23.07%) children is an indication of microbial stimulation. The results of the study show that the majority of patients with ARI have an imbalance in the local secretory immunity in the acute period, which requires the search for modern methods of correction, depending on the results obtained.