The role of neurospecific proteins in the assessment of psychomotor development in the children with perinatal asphyxia

Abstract

The role of neurospecific proteins in assessing the psychomotor development of preterm infants under 1 year of age with perinatal asphyxia has been identified. 180 infants were assessed at the age of 1 year by the Denver test and underwent clinical laboratory examination. During assesment of the Denver II scale, developmental delays were observed in various areas - both motor function and speech development and social adaptation. Delayed psychomotor development was found in all infants with ventriculomegaly and cerebral atrophy (100%), and 75-86.5% was observed in the infants with grade III intraventricular hemorrhage and hydrocephalus, respectively.
The relationship between psychomotor delay and neurochemical indicators has been identified. It was found that there is a significant change in neurochemical parameters (BDNF, NSE) in the neonatal period compared to normal developing infants.Thus, these changes in the level of neurospecific proteins in the neonatal period have shown their clinical significance in the dynamics in the form of changes of psychomotor development of the child and confirmed their retrospective-prospective prognostic value.