Risk factors and clinical and immunological aspects of perinatal infections in preterm infants

Abstract

The aim of the study was to examine the risk factors for implementing the perinatal infections and their clinico-immunological features in preterm infants. A complex clinical and laboratory examination of 433 preterm infants with perinatal infections (gestational age 27-37 weeks) were conducted. Determination of the level of IL-1β, IL-6, IL-10, IL-18, TNF-α run by standard solid-phase enzyme immunoassay ('sandwich'-ELISA) . Applied methods of variational, correlation, discriminant, dispersion and ROC analyses. Established risk factors for implementation of perinatal infection in preterm infants are extrage-nital pathology, obsessed by gynecological history (miscarriages), pregnancy complications (gesto-sis, anemia), the threat of termination of pregnancy, gestational age. Reliable diagnostic criteria for infection are increased level of proinflammatory cytokines and lower level anti-inflammatory cyto-kines. The correlations were identified between risk factors for implementation of perinatal infec-tions, immunological parameters, clinical manifestations that characterize the severity of the dise-ase.