Spontaneous Intestinal Perforation (SIP) is one of severe gastrointestinal disorders usually occurring without a defined prodrome in premature infants in the first 1-2 weeks of life which requires surgical intervention. SIP is a distinct clinical entity and has better outcome than neonates with intestinal perforation secondary to Necrotizing Enterocolitis (NEC). This article presents the clinical, diagnostic and prognostic differences of SIP and NEC
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