Cytokine profile of newborns with seizures

Abstract

The aim of the study was to assess the level of cytokines in newborn children of various gestational ages with seizures. A prospective, comprehensive study of 307 newborns of various gestational ages with seizures was carried out. Changes in immunological reactivity in newborns with seizures are manifested in an abnormality of the cytokine status and a significant increase in pro-inflammatory cytokines (IL-1β by 1.9; IL-6 by 3 times; TNF-α by 3.3 times) in relation to newborns of the control group. The increased concentration of pro-inflammatory cytokines in newborns with HIE leads to the maintenance of seizure activity and aggravates further unfavorable neurological outcome. It was revealed that cerebral disorders and dysfunction of a number of organs and systems are correlated with the parameters of the immune systemin neonatal seizures. Thus, the expression of pro-inflammatory cytokines can be used as a screening marker in the diagnosis and prediction of neonatal seizures on the background of perinatal hypoxic - ischemic lesions of the central nervous system.