The role of SIGIRR in formation of necrotizing enterocolitis in infants with intrauterine infection
Abstract
Necrotizing Enterocolitis is one of the actual problems of neonatology, that primarily affects premature infants, particularly those born before 32 weeks of gestation. The aim of this study is to investigate the role of genetic factors in the development of both necrotizing enterocolitis and intra- uterine infection, exploring the possible links between these two conditions. A total of 52 with NEC and 10 healthy, were included in this study. All the examined children with NEC were divided into 2 groups: 19 newborns with intrauterine infection (1st subgroup), 33 infants without intrauterine infection (2nd subgroup). It was determined SIGIRR gene mutations with DNA isolation and standardized PCR reactions. It was found that C58 gene locus changes is a potential predictive marker for differentiating between infants with intrauterine infection and NEC and those without these conditions. Genetic screening may help identify infants at higher risk of developing NEC, allowing for targeted
interventions and personalized care.
References
Alganabi M, Lee C, Bindi E, Li B, Pierro A. Recent advances in understanding necrotizing enterocolitis. F1000Res. 2019, 8.
Duchon J, Barbian ME, Denning PW. Necrotizing Enterocolitis. Clinics in Perinatology. 2021, 48(2):229-50.
Meister AL, Doheny KK, Travagli RA. Necrotizing enterocolitis: It’s not all in the gut. Exp Biol Med (Maywood). 2020, 245(2):85-95.
Bisquera JA, Cooper TR, Berseth CL. Impact of necrotizing enterocolitis on length of stay and hospital charges in very low birth weight infants. Pediatrics. 2002, 109:423–8.
Neu J, Walker WA. Necrotizing enterocolitis. N Engl J Med. 2011, 364:255–64.
Schnabl K.L., Aerde J.E.V., Thomson A.B., Clandinin M.T. Necrotizing enterocolitis: A multifactorial disease with no cure. World J. Gastroenterol. 2008, 14:2142–2161. doi: 10.3748/ wjg.14.2142.
Hackam D.J., Sodhi C.P. Toll-like receptor-mediated intestinal inflammatory imbalance in the pathogenesis of necrotizing enterocolitis. Cell. Mol. Gastroenterol. Hepatol. 2018, 6:229–238.e1. doi: 10.1016/j.jcmgh.2018.04.001.
Sampath V., Menden H., Helbling D., Li K., Gastonguay A., Ramchandran R., Dimmock D.P. SIGIRR genetic variants in premature infants with necrotizing enterocolitis. Pediatrics. 2015, 135:e1530–e1534.
Neal M.D., Sodhi C.P., Dyer M., Craig B.T.,Good M. et al. A critical role for TLR4 induction of autophagy in the regulation of enterocyte migration and the pathogenesis of necrotizing enteroco- litis. J Immunol. 2013, 190: 3541-3551
Wang J., Ouyang Y., Guner Y., Ford H.R., Grishin A.V. Ubiquity-editing enzyme A20 promotes tolerance to lipopolysaccharide in enterocytes. J Immunol. 2009, 183: 1384-1392
Hackam DJ, Sodhi CP. Toll-Like Receptor–Mediated Intestinal Inflammatory Imbalance in the Pathogenesis of Necrotizing Enterocolitis. Cellular and Molecular Gastroenterology and Hepatology. 2018;6(2):229-38.e1.
Wu W.. Wang Y. Zou J., Long F. Bifidobacterium adolescentis protects against necrotizing enterocolitis and upregulates TOLLIP and SIGIRR in premature neonatal rats// BMC
Keywords
Most read articles by the same author(s)
- Aliyeva A.M, Nasibova S.N., Multiple deficiency of adenohypophisis hormones. , Azerbaijan Journal of Perinatology and Pediatrics: Vol. 7 No. 2 (2021): JOURNAL OF AZERBAIJAN PERINATOLOGY AND PEDIATRICS