Сharacteristics of metabolic processes in neonates with perinatal asphyxia

Abstract

The aim of the study is to evaluate the role of metabolic processes in organ and system damage in newborns with perinatal asphyxia. 98 newborns (54 premature, 44 full-term) with perinatal asphyxia (PA) were included in the study. The severity of the condition of the examined children was determined according to the NEOMOD scale in the early neonatal period. Newborns are divided into 2 groups; The 1st main group included 58 children who were evaluated with the maximum score (5 points and higher) in the early neonatal period, and 40 children who were evaluated with a score of 4 points and less were assigned to the 2nd comparison group. The concentration of serotonin, lipid peroxidation indicators, antioxidant system and Ca, P homeostasis in newborns who underwent PA were determined by biochemical and immunoassay methods on days 5-7, 10-14 and 24-28 in the dynamics of the neonatal period. During the examination of metabolic processes in newborns who underwent PA, it was found that this process changes depending on the severity of the child’s condition and gestational age in the dynamics of the neonatal period and leads to organ and system damage. It has been established that identifying severe metabolic changes can lead to timely prevention of these injuries