Modern concepts on inflammation of bronchial lung tissue during respiratory diseases in children

Abstract

In recent years, the interest in examining expiratory air condensate as non-invasive methods, including detection of up to 1,000 substance, in order to determine the features of inflammation of bronchial lung tissue processes in children has been significantly increased .
Researchers are particularly interested in the determination of nitrogen oxide (NO) in expiratory air condensate (EAC), which is one of the respiratory tract markers. It participates in many physiological and pathological processes in many organisms. Increased NO concentration in newborns with perinatal asphyxia is noted. There is a synthesis of a plenty NO in the center of defeat .NO concentration plays an important role in regulating protein synthesis in the extracellular matrix of the lungs. The definition of NO in respiratory tracts should be regarded as a supplement to traditional clinical diagnostic methods. The level of NO metabolites in the EAC depends on many factors and dictates the research in this aspect .
Study of fatty acids in EAC shows that linoleic acid reduced in children during pneumonia , polyunsaturated acids increased related to the activity of the LPO process.
Thus, after the analysis of literature data, it should be noted that the expiratory air metabolites are not widely used in pediatrics despite of all the advantages. All studies are mainly related to the identification of different indicators in the EAC, and the work of children is one.
Diagnosis, differential diagnosis, prediction and outcome of respiratory diseases in non-invasive methods, especially in neonatal period, remain as actual problems of pediatrics and pulmonology.