SARS-CoV-2-associated venous cerebral sinus Thrombosis
Abstract
Venous thrombosis is a pathological condition in which, as a result of the formation of an intravascular thrombus, the blood flow in the tissues is abruptly interrupted or limited. A number of studies have shown that in adults, activation of the blood coagulation system against the background of a cytokine storm due to SARS-CoV-2 led to ischemic stroke and intracranial hemorrhage.An analysis of numerous studies in children with systemic inflammatory syndrome revealed an unexpectedly high incidence of ischemic and hemorrhagic cerebrovascular complications in them. Our article describes the clinical picture of parenchymal hemorrhage, as well as thrombosis of the cerebral venous sinuses in a newborn, which developed as a result of a multisystem inflammatory syndrome associated with SARS-Cov2.
References
Ferro J.M., Canhao P., Stam J. et al. Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT) // Stroke. 2004. Vol. 35. Р.664–670. PMID:14976332. doi:10.1161/01.STR.0000117571.76197.26
Максимова М.Ю. , Дубовицкая Ю.И. , Брюхов В.В. , Кротенкова М.В.Диагностика тромбоза мозговых вен и венозных синусов «РМЖ» №21 от 24.10.2017 стр.1595-1601.
Mohamad Abdalkader , Shamsh P Shaikh , James E Siegler , Anna M Cervantes-Arslanian and et al.Cerebral Venous Sinus Thrombosis in COVID-19 Patients: A Multicenter Study and Review of Literature / J Stroke Cerebrovasc Dis. 2021 Jun;30(6):105733
YaseminDinç, GizemGüllü, Bahattin Hakyemez, Mustafa Bakar. Juxtacortical Hemorrhage in Cerebral Venous Thrombosis: Cashew Nut Sign. Turk J Neurol2021;27:349-350,p.349
Ezgi Sezer Eryildiz Atilla Ozcan Ozdemir. Clinical Features of Cerebral Venous Sinus Thrombosis/SerebralVenoz Sinus Trombozunun Klinik Ozellikleri.Turkish Journal of Neuro-logy,Vol. 23, Issue 3,2017
Yang YK, Chan AKC, Callen DJA, Paes BA. Neonatal cerebral sinovenous thrombosis: sifting the evidence for a diagnostic. Pediatrics. 2010;126(3):e693–e700.
Berfelo FJ, Kersbergen KJ, van Ommen CH, et al. Neonatal cerebral sinovenous thrombosis from symptom to outcome. Stroke. 2010;41:1382–1388.
Moharir MD, Shroff M, Stephens D, et al. Anticoagulants in pediatric cerebral sinovenous thrombosis: a safety and outcome study. Ann Neurol. 2010;67:590–599.
Nwosu ME, Williams LS, Edwards-Brown M, et al. Neonatal sinovenous thrombosis: presentation and association with imaging. Pediatr Neurol. 2008;39:155–161.
Grunt S, Wingeier K, Wehrli E, et al. for the Swiss Neuropaediatric Stroke Registry. Cerebral sinus venous thrombosis in Swiss children. Dev Med Child Neurol. 2010;52:1145–1150.
Cursi, L.; CaloCarducci,F.I.; Chiurchiu, S.; Romani, L.; Stoppa,F.; Lucignani, G.; Russo, C.; Longo, D.;Perno, C.F.; Cecchetti, C.; et al. Severe COVID-19 Complicated by Cerebral Venous Thrombosis in a Newborn Successfully Treated with Remdesivir,Glucocorticoids, and Hyperimmune Plasma. Int. J. Environ. Res. PublicHealth2021, 18, 13201. https://doi.org/10.3390/ijerph182413201.
Niazkar HR, Zibaee B, Nasimi A, Bahri N. The neurological manifestations of COVID-19: a review article. NeurolSci2020; 41: 1667–71.
Pouletty M, Borocco C, Ouldali N, et al. Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort. Ann Rheum Dis 2020; 79: 999–1006.
Kaur S, Bansal R, Kollimuttathuillam S, et al. The looming storm: blood and cytokines in COVID-19. Blood Rev 2020; published online Aug 18. https://doi.org/10.1016/j.blre.2020.100743.
Chen TH. Neurological involvement associated with COVID-19 infection in children. J NeurolSci2020; 418: 117096.
Li Y, Li M, Wang M, Zhou Y, Chang J, Xian Y идр. (2020) Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study.Stroke Vasc. Neurol. 2020; 5 (3): 279–284.
Mowla A, Shakibajahromi B, Shahjouei S, Borhani-Haghighhi A, Rahimian N, Baharvahdat H et al.Cerebral venous sinus thrombosis associated with SARS-CoV-2; a multinational case series J Neurol Sci.2020; 419:117183
Keywords
multisystem inflammatory syndrome
cerebral venous sinus thrombosis yenidoğulan
multisistem iltihab sindromu
serebral venoz sinus trombozu. новорожденный
мультисистемный воспалительный синдром
тромбоз церебрального венозного синуса