Дефицит иммунной (ИД) системы представляет собой группу заболеваний, вызванных дефицитом белков, цитокинов, рецепторов цитокинов у одной или нескольких групп клеток. ИД повышает восприимчивость к инфекционным процессам, вызывает аутоиммунные заболевание и лимфопролиферацию. Первичные иммунодефициты (ПИД)
- это врожденные дефекты, которые влияют на развитие и / или функцию иммунной системы, и в основном наследуются (аутосомно-рецессивный или X-хромосомно- зависимый путь). Признаки первичного иммунодефицита у детей начинаются с рождения, часто проявляется в виде внутриклеточных и вирусных инфекций.
Ç.Aydoğmuş, R.Şiraneci. İmmün Yetersizlikte Tanısal Yaklaşım; JOPP Derg 2(2):52-54, 2010
M.Sütçü, A.Somer. Çocuklarda İmmün Yetmezliklere Yaklaşım, Çocuk Dergisi 14(2):62-65, 2014
Arkwright PD, GenneryAR.Ten warning signs of primary immunodeficiency: a new paradigm is needed for the 21st century. Ann AcadSci 2011;1238:7-14.
T.Turul, İ.Tez. Primer İmmun Yetmezlik Hastalıklarına yaklaşım, 2003,cilt 12
DeVries E, Driessen G. Educational paper: primary immunodeficiencies in children: a diagnostic challenge. Eur J Pediatr. 2011;170(2):169–177.
D.Ç.Ayvaz; Primer immun yetmezliklere yaklaşım,; Katkı Pediatri Dergisi 2011; 33 (2);85-98.
FM Tosi. Normal and Impaired Immunologic Responses to Infection. Textbook of Pediatric Infectious D., 7th Edition, Philadelphia. 2014: 55-106.
Dhrubajyoti Sharma et al.Approach to a Child with Primary Immunodeficiency Made Simple, Indian Dermatol J. 2017 Nov-Dec; 8(6): 391–405.
Norouzi S, Aghamohammadi A, Mamishi S and etc. BCG complications associated with primary immunodeficiency diseases. J Infect 2012;64:543-54
Aziz Bousfiha, LeïlaJeddane et al.The 2017 IUIS Phenotypic Classification for Primary Immunodeficiencies;J ClinImmunol. 2018; 38(1): 129–143.
Notarangelo LD, Fischer A, Geha RS, et al; Primary immunodeficiencies: J Allergy ClinImmunol. 2009; 124(6):1161–1178.
De Vries E.Patient-center screening for primary immunodeficiency:a multistage diagnostic protocol designed for non-Immunologists.Immunol 2006: 204-14.
Casanova JL, Abel L. Primary immunodeficiencies: a field in its infancy. Science 2007; 317:617-9.
Orange JS. Clinical update in immunoglobulin therapy for primary immunodeficiency diseases; Immune Deficiency Foundation; 2012.
Notarangelo LD. Primary immunodeficiencies. J Allergy ClinImmunol 2010; 125:182-94.
Picard C, Al-Herz W, Bousfiha A, et al. Primary Immunodeficiency Diseases: J ClinImmunol. 2015; 35:696–726.
Buckley HR. Evaluation of suspected immunodeficiency. In: Behrman RE, Kliegman RM.18th ed. Philadelphia: Saunders, 2007: 867-73.
Gathmann B, Grimbacher B, Beauté J, et al.; The European Internet-based patient and research database for primary immunodeficiencies: 2009; 157:3-11.
ARIN E. REUST, MD, MSPH, University of Missouri School of Medicine, Columbia. 2013 Jun 1;87(11):773-778
Joshi AY, Iyer VN, Hagan JB et al. Incidence and temporal trends of primary immunodeficiency: a population-based cohort study. 2009; 84(1):16–22.
E.Ayaşlıoğlu. Hücresel İmmün Yetmezlikler ve İnfeksiyon, Kırıkkale Üniversitesi Tıp Fakültesi 2014: 4:142-149.
Hauk PJ, Johnston RB,et al. Immunodeficiency evaluation: primary considerations. Pediatrics 20th ed. Columbus,: December 1, 2011
Slatter MA, Gennery AR. Clinical immunology review series: an approach to the patient with recurrent infections in childhood. 2008; 152(3):389–396.
Turvey SE, Bonilla FA, Junker AK. Primary immunodeficiency diseases: a practical guide for clinicians. Postgrad Med J 2009; 85:660-6.
Singh S, Gupta S. Primary Immunodeficiency Diseases: Need for Awareness and Advocacy in India. Indian J Pediatr. 2016; 83:328–30.
Cunningham-Rundles C. Autoimmunity in primary immune deficiency: Taking lessons from our patients. ClinExpImmunol. 2011;164:6–11.
Panel on Antiretroviral Therapy and Medical Management of HIV-Infected Children. Guidelines November 5, 2012.
Immune Deficiency Foundation SCID Newborn Screening. New year, new updates on SCID screening. Accessed December 11, 2012.
Railey MD, Lokhnygina Y et al. Long-term clinical outcome of patients with SCİD who received related donor bone marrow transplants or post-transplant GVHD prophylaxis. J Pediatr. 2009;155(6):834–840.e1.
Lipstein EA, Vorono S, et al. Systematic evidence review of newborn screening and treatment of SCİD. Pediatrics. 2010;125(5):e1226–e1235.
Routes JM, Grossman WJ, Verbsky J, et al. Statewide newborn screening for severe T- cell lymphopenia. JAMA. 2009;302(22):2465–2470.
Comeau AM, Hale JE, Pai SY, et al. Guidelines for implementation of population-based newborn screening for SCİD. 2010;33:S273–S281.
Vaccination of Persons with Primary and Secondary İmmune Deficiencies. Table 8- 1,ACIP General Best Practice Guidelines for Immuniz.; March 2018.