e-ISSN: 2664-1194     print ISSN: 2304-6554
The role of cytokines in the development and prognosis of neonatal sepsis in preterm infants
Azerbaijan Journal of Perinatology and Pediatrics

Abstract

The study of the clinical features of neonatal sepsis, the prediction of its course, remains relevant in scientific and practical aspects. The study showed that, the main cause of heterogeneous sepsisin preterm newborns with different gestational age, depending on severity of sepsis are the immaturity of the immune system, the activation of inflammatory mediators as a result of the appearance of various disorders of systems and organs in the acute phase of the disease. In this respect, the detection of cytokines (inflammatory mediators) in children with different gestational ages and neonatal sepsis can predict the course of sepsis.

References

Ugur Dilmen. Erken ve gecikmiş sepsis . ” Neonatoloji ”. 2010. s.231-235.

Annane D, Siami S, Jaber S, et al; Cristal Investigators. Effects of fluid resus-citation with colloids vs crystalloids on mortality in critically ill patients presenting with septik shock: the CRISTAL randomized trial. JAMA 2013; 310:1809–1817.

Abdallah MW., LarsenN., Mortenson EL. “Neonatal Levels cytokines and risk of infections. // J. Newimmunol.2012.252 (1-2). p.75-82.

Dellinger RP, Levy MM, Rhodes A, et al; Surviving Sepsis Campaign Guidelines Committee including the Pediatric Sub-group. Surviving sepsis campaign: internatio-nal guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 2013; 41:580–637. 5.Benitzw E.,BellissantE.,Kupfer Y., Keh D. // Corticosteroids for treating severe sepsis and septic shock.Pediatr. Infect. Dis. J. 2015. Vol.27. p.372-379.

PolinRC., Lorenz JM. Shock. Pocket Clinician Neonatology . NewYork. Cambrid-ge UniversityPress. 2014. p. 292-297.

Camacho-Gonzales A., Castelli G.P., Pognani C., Cita M. Procalcitonin, C-reaktive protein, white blood cells and SOFA score in ICU: diagnosis and monitoring of sepsis. // Minerva Anestesiol. 2013. Vol.72. p .69-80.