Characteristics of lipid metabolism in newborns with perinatal asphyxia

Abstract

The aim of the study: is to study the characteristics of lipid metabolism and the state of the antioxidant system in newborns with perinatal asphyxia, of different gestational ages. 98 newborns (54 premature, 44 born on time) who had perinatal asphyxia and were admitted to the intensive care unit in the early neonatal period were included in the study.
The gravity of the situationof the examined children was determined according to the NEOMOD scale in the early neonatal period. The indicators of LPO (malondialdehyde, catalase, glutathione peroxidase) and AOF in the blood serum were determined by the biochemical method on days 5-7, 10-14 and 24-28 of the child's life. The level of MDA, catalase, QPO in the main group newborns on day 5-7 was significantly higher (p<0.01) than the control and comparison group, and the level of AOA was significantly lower (p<0.01) than the control group. During the individual analysis of the observed changes in the level of LPO and AOF, it was observed that their level was significantly different (higher or lower) than the control group in both the main and the comparison group, which manifested itself in the form of a wide has shown margin of error. İn neonates with perinatal asphyxia, the concentration of LPO indicators (MDA, Catalase, QPO) and the level of AOF vary depending on the severity of the pathological process, the gestational age of the child and the leading clinical syndrome in the dynamics of the neonatal period.