The association of immunogenetic markers from the HLA system in couples with congenital malformations of the fetus in the anamnesis

Abstract

Congenital malformations can cause miscarriages and stillbirths. They can be life-threatening, cause disability. A key role in the immune interactions between mother and hemialleogennym embryo genes play a major histocompatibility complex (HLA).
29 married couples with a history of children with congenital malformations were examined. Parents were typed at the locus HLA-DR and HLA-DQ. Comparison of matrimonial haplotypes showed that in 20.7% of cases, the similarity of the 1 allele was noted and the clubfoot, hypospadias, cleft palate were determined. Similarity in the 2 alleles was found in 13.8% - hypospadias, congenital heart disease, multiple malformations. The similarity in the 3 alleles was also noted in 13.8% of pairs. In these cases, anencephaly, multiple malformations, hydrocephalus were detected.