Multisystem inflammatory syndrome in newborn

Abstract

Neonatal multisystem inflammatory syndrome (Multisystemic inflammatory syndrome in newborns, MIS-N) is an inflammatory process associated with SARS-CoV-2 in which there is an activation of the immune system, the release of pro-inflammatory cytokines and inflammation markers, multiple organ failure, which can be the cause of death in newborns. Clinical manifestations of the multisystem inflammatory syndrome are non-specific, especially in premature infants, usually in newborns there is temperature lability, weak sucking, lethargy; respiratory disorders, cardiovascular failure. If you suspect MIS-N in the blood, you should determine Ig G and Ig M to SARS-CoV2, the level of inflammatory markers (C-reactive protein, procalcitonin), ferritin, D-dimer, NT-Pro BNP, IL-6, which will allow you to make a timely diagnosis, prescribe appropriate treatment and thereby prevent the death of newborns. For a more indepth understanding of the SARSCoV-2 flow characteristic of the infection in newborns, larger epidemiological and clinical cohort research is needed.