Some clinical and diagnostic aspects of a cystic fibrosis

Abstract

The aim of investigation was studying of value of clinical signs and laboratory and other researching methods in diagnosis of a cystic fibrosis in children.
Materials and methods. 142 children aged from 3 months up to 12 years with suspicion on CF were observed. Clinical symptoms, results of the sweat test and genetic analysis were estimated at all patients. Additional researches and consultations of specialists were performed if necessary.
Results.The diagnosis of CF was confirmed in 17 children. İn 7 (41,2%) children in establishment of the diagnosis the defining role was played by the genetic analysis, in 10 (58,8%) patients the diagnosis was confirmed on the basis of clinic, repeated (2-3 multiple) carrying out the sweat test, and additional researches (the computed tomography of a thorax was carried out to 7 patients, assessment of function of a pancreas (definition of elastase 1 in a feces) – to 3 children, bronchopulmonary lavage- to 2 children, ultrasound examination of abdominal organs – to 10 children, a liver biopsy - to 1 child, magnetic resonance imaging of an abdominal cavity- to 1 child, allocation of a Pseudomonas aeruginosa from a sputum – to 10 children, 8 children were consulted by the otorhinolaryngologist).
Conclusions. Data of our research allow to claim that in practice any of clinical and laboratory signs can't independently be the basis for reliable diagnosis, so all signs must be evaluated in complex.