The features of innate immunityin preterm babies with sepsis

Abstract

The main goal of the study was the detection of changes in serum levels of cytokines (IL-1β, IL-6, TNF-α, INF-α, INF-γ) in preterm babies with sepsis and the study of pathogenetic and prognostic significance. 36 preterm babies have been examined. The control group consisted of 25 healthy preterm babies. Changes in innate immunity in sepsis were characterized by the development of an imbalance between cytokine indicators (interleukins IL-1β, IL-6, TNF-α, inhibition of the synthesis of INF-α, INF-ions and other INF-γ) and decreasingimmune response of effector function. The obtained scientific results allow to reveal new mechanisms of pathogenesis of sepsis in preterm babies and to develop immunocorrective therapy.
Elevated levels of circulating ferritin in the blood testifies the development of the infectious process and its intensity in preterm babies.