Multiple deficiency of adenohypophisis hormones.

Abstract

Multiple deficiency of adenohypophysis hormones (MDAH) is a rare disease caused by dysfunction of the pituitary gland and characterized by a deficiency of growth hormone, as well as one or more trop hormones. Congenital hypopituitarism is most common in childhood. The exact causes of the disease remain unclear. Mutations in the PROP1 gene are known to cause genetically conditioned MDAH in children. According to the literature, mutations in this gene are found in 50- 80% of familial cases of ASD. According to international studies, patients with mutations in the PROP1 gene have significant stunting due to intrauterine somatotrophic hormone (STH) and thyrotropic hormone (TTH) deficiency. Patients with MDAH have total STH deficiency, secondary hypothyroidism and secondary hypoganadism.